Targeted and image-guided photodynamic cancer therapy based on organic nanoparticles with aggregation-induced emission characteristics.

نویسندگان

  • Youyong Yuan
  • Guangxue Feng
  • Wei Qin
  • Ben Zhong Tang
  • Bin Liu
چکیده

We report for the first time that organic nanoparticles with photodynamic activity and aggregation-induced emission characteristics are developed for targeted and image-guided photodynamic cancer therapy.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Targeted and Imaging-guided In Vivo Photodynamic Therapy of Tumors Using Dual-functional, Aggregation-induced Emission Nanoparticles

Imaging-guided photodynamic therapy (PDT) has been regarded as a promising strategy for precise cancer treatment. Because of their excellent modifiability and drug loading capacity, nanoparticles have played an important role in PDT. However, when traditional photosensitizers are made into nanoparticles, both their fluorescence and reactive oxygen species (ROS) generation efficiency are decreas...

متن کامل

Multifunctional organic nanoparticles with aggregation-induced emission (AIE) characteristics for targeted photodynamic therapy and RNA interference therapy.

We report the design of AIE fluorogen (AIEgen)-based multifunctional organic nanoparticles with surface siRNA decoration for targeted photodynamic therapy and RNA interference therapy.

متن کامل

Image-guided combination chemotherapy and photodynamic therapy using a mitochondria-targeted molecular probe with aggregation-induced emission characteristics† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c5sc00826c Click here for additional data file.

Subcellular targeted cancer therapy and in situ monitoring of therapeutic effect are highly desirable for clinical applications. Herein, we report a series of probes by conjugating zero (TPECM-2Br), one (TPECM-1TPP) and two (TPECM-2TPP) triphenylphosphine (TPP) ligands to a fluorogen with aggregation-induced emission (AIE) characteristics. The probes are almost non-emissive as molecularly disso...

متن کامل

Image-guided combination chemotherapy and photodynamic therapy using a mitochondria-targeted molecular probe with aggregation-induced emission characteristics.

Subcellular targeted cancer therapy and in situ monitoring of therapeutic effect are highly desirable for clinical applications. Herein, we report a series of probes by conjugating zero (TPECM-2Br), one (TPECM-1TPP) and two (TPECM-2TPP) triphenylphosphine (TPP) ligands to a fluorogen with aggregation-induced emission (AIE) characteristics. The probes are almost non-emissive as molecularly disso...

متن کامل

Numerical study of thermal dynamics of gold nanoparticles in laser-induced hyperthermia therapy

Damage of the normal tissue is a serious concenrn in cancer treatment. Hyperthermia by laserhas been considered as a safe cancer treatments methods with lower harmful effects on normaltissues. Using nanoparticles in cancer treatment has improved laser therapy, which is based ona selective cell targeting method to localize cell damages. Metallic nanoparticles such as gold,silver, and copper have...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • Chemical communications

دوره 50 63  شماره 

صفحات  -

تاریخ انتشار 2014